![]() Numerous studies suggest that activation of the Nrf2–ARE pathway in the brain confers protection to vulnerable neurons, making neuronal Nrf2 up-regulation an attractive therapeutic strategy for PD. Under such conditions, the transcription factor NF-E2-related factor (Nrf2) binds to antioxidant response element (ARE) to induce antioxidant and phase II detoxification enzymes. Oxidative stress has been implicated in the etiology of Parkinson’s disease (PD).
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